A Novel Psychopathological Model Explains the Pathogenesis of Gastric Ulcers

The first detailed description of the morphology gastric ulcer was reported ~230 years ago, but mechanism has yet to be elucidated. Moreover, peptic ulcers, including duodenal and are currently considered an infectious disease caused by Helicobacter pylori, how infection leads ulceration remains elusive. To address these challenges, a recently published Complex Causal Relationship applied analyze existing data. Peptic ulcers were identified as psychosomatic triggered psychological stress, where pylori plays secondary role in only late phase disease. This etiology explained all characteristics observations/phenomena series 6 articles. second article focused on pathogenesis ulcers. Based hereditary predisposition, accumulation past life experiences incurs formation negative lifeview. Consequently, individual tends negatively evaluate themselves or current events, leading acute stress. stress triggers release aberrant neurotransmitters central nervous system, which turn cause transmission pathogenic nerve impulses stomach, resulting ‘pre-ulcer lesion’ wall eventually, ulcer. psychopathological model elucidated 12 24 ulcer, along with roles acid, NSAIDs. effectiveness suggests that theoretical research empirical study equally important medical explorations, guiding philosophy indispensable for major progress science medicine.